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Serine/Arginine Rich Splicing Factor 6 (SRSF6)

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SFRS6; B52; SRP55; Pre-mRNA-splicing factor SRP55; Splicing factor, arginine/serine-rich 6

Serine/Arginine Rich Splicing Factor 6 (SRSF6)
CCC F106
HGNC 10788
MGI 1915246
PubMed 23132731
RGD 1359241
UniProt Q13247
SFRS6 is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Screaton et al. (1995) isolated a cDNA representing the human homolog of Drosophila B52/SRp55, which was later identified as SFRS6. Human SRp55 is similar in length to the Drosophila homolog (344 vs 350 or 376 amino acids) and 64% similar to it in amino acid sequence. Screaton et al. (1995) obtained evidence for alternative splicing of the human gene. Recombinant SRp55 protein was able to restore splicing to a cytosolic S100 extract deficient in all SR proteins, showing that SRp55 functions in mRNA formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 6 (SRSF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 6 (SRSF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 6 (SRSF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 6 (SRSF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 6 (SRSF6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 6 (SRSF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 6 (SRSF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 6 (SRSF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 6 (SRSF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 6 (SRSF6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 6 (SRSF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 6 (SRSF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 6 (SRSF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 6 (SRSF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 6 (SRSF6) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein."Mol. Cell. Biol. 20:3049-3057(2000) [PubMed] [Europe PMC] [Abstract]
  7. "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing."Biochemistry 42:951-957(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors."J. Neurochem. 88:1078-1090(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion."J. Biol. Chem. 287:30497-30506(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Splicing factor SRSF6 promotes hyperplasia of sensitized skin."Nat. Struct. Mol. Biol. 21:189-197(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]