≡

Serine/Arginine Rich Splicing Factor 7 (SRSF7)

[Edit]

SFRS7; 9G8; AAG3; HSSG1; RBM37; ZCCHC20; ZCRB2; Splicing factor 9G8; Splicing factor, arginine/serine-rich 7

Serine/Arginine Rich Splicing Factor 7 (SRSF7)
CCC F107
HGNC 10789
MGI 1926232
PubMed 7629084
UniProt Q16629
Wiki SFRS7
The isolation and characterization of cDNA clones indicated that the 9G8 protein (SFRS7) is a member of the serine/arginine (SR) splicing factor family because it includes an N-terminal RNA binding domain and a C-terminal SR domain. Members of this family are thought to play key roles in alternative splicing. The RNA binding domain of 9G8 is closely related (79 to 71% identity) to those of the SR factors human SRp20 and Drosophila RBP1.
The gene spans 7,745 bp and consists of 8 exons and 7 introns within the coding sequence, thus contrasting with the organization of some other genes of the SR splicing factor family. The 5-prime flanking region is GC-rich and contains basal promoter sequences and potential regulatory elements.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 7 (SRSF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 7 (SRSF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 7 (SRSF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 7 (SRSF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 7 (SRSF7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 7 (SRSF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 7 (SRSF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 7 (SRSF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 7 (SRSF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 7 (SRSF7) ELISA Kit Customized Service Offer
  1. "Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family."EMBO J. 13:2639-2649(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts."J. Biol. Chem. 270:17830-17835(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-alpha 1 mRNA."Med. Mol. Morphol. 43:145-157(2010) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA."Mol. Cell 7:899-905(2001) [PubMed] [Europe PMC] [Abstract]
  8. "CDK11 complexes promote pre-mRNA splicing."J. Biol. Chem. 278:8623-8629(2003) [PubMed] [Europe PMC] [Abstract]
  9. "SR splicing factors serve as adapter proteins for TAP-dependent mRNA export."Mol. Cell 11:837-843(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells."J. Biol. Chem. 279:11639-11648(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization."J. Biol. Chem. 279:35788-35797(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors."J. Neurochem. 88:1078-1090(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP."Proc. Natl. Acad. Sci. U.S.A. 105:5154-5159(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8."EMBO J. 25:5126-5137(2006) [PubMed] [Europe PMC] [Abstract]