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Serine/Arginine Rich Splicing Factor 8 (SRSF8)

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SWAP; SFRS8; SFSWAP; Suppressor of white apricot protein homolog; Splicing factor, suppressor of white-apricot homolog

Serine/Arginine Rich Splicing Factor 8 (SRSF8)
CCC F108
HGNC 10790
MGI 101760
PubMed 15103716
RGD 1305004
UniProt Q12872
SFRS8 encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Multiple alternatively spliced variants have been identified although their full-length natures have not been characterized to date.
The human gene encodes a 951-amino acid polypeptide containing putative nuclear localization sequences, an arginine- and serine-rich (R/S) domain, and 2 repeated modules, known as surp modules, which are homologous to regions in the constitutive splicing factor SPP91/PRP21. SWAP expression is regulated, presumably autogeneously, by control of splicing of the first 2 introns.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 8 (SRSF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 8 (SRSF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 8 (SRSF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 8 (SRSF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 8 (SRSF8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 8 (SRSF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 8 (SRSF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 8 (SRSF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 8 (SRSF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 8 (SRSF8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 8 (SRSF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 8 (SRSF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 8 (SRSF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 8 (SRSF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 8 (SRSF8) ELISA Kit Customized Service Offer
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  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS."J. Biol. Chem. 271:31106-31114(1996) [PubMed] [Europe PMC] [Abstract]
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  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the SURP1 and SURP2 domain in splicing factor, arginine/serine-rich 8."Submitted (JUN-2007) to the PDB data bank