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Splicing Factor 4 (SF4)

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SUGP1; RBP; SURP And G Patch Domain Containing 1; RNA-binding protein RBP

Splicing Factor 4 (SF4)
CCC F114
HGNC 18643
MGI 1917866
PubMed 12594045
RGD 1310496
UniProt Q8IWZ8
SF4 is a member of the SURP family of splicing factors. By EST database searching and genomic sequence analysis, Sampson and Hewitt (2003) identified 2 related members of the SURP family, which they called SF4 and SFRS14. SF4 encodes a deduced 645-amino acid protein with an estimated molecular mass of 72.5 kD. Both SF4 and SFRS14 contain 2 SURP motifs and a single G-patch domain in their C termini. Sampson and Hewitt (2003) also cloned the mouse orthologs; the mouse Sf4 protein shares an identical domain organization and 89% sequence identity with its human counterpart. Northern blot analysis detected expression of an approximately 2.1-kb SF4 transcript in all human fetal and adult tissues tested, with the exception of adult liver. The highest expression was detected in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 4 (SF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 4 (SF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 4 (SF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 4 (SF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 4 (SF4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 4 (SF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 4 (SF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 4 (SF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 4 (SF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 4 (SF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 4 (SF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 4 (SF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 4 (SF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 4 (SF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 4 (SF4) ELISA Kit Customized Service Offer
  1. "SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11."Gene 305:91-100(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Large-scale proteomic analysis of the human spliceosome."Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]