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Ubiquitin Specific Peptidase 13 (USP13)

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ISOT3; IsoT-3; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin Carboxyl-Terminal Hydrolase 13; Isopeptidase T-3; Ubiquitin Specific Protease 13

Ubiquitin Specific Peptidase 13 (USP13)
CCC F133
HGNC 12611
MGI 1919857
PubMed 21962518
UniProt Q92995
Wiki USP13
Isopeptidase T (ISOT) is a deubiquitinating enzyme and a member of the family of ubiquitin-binding proteins (UBPs). UBPs contain a catalytic core of approximately 300 amino acids located between conserved cysteine and histidine boxes.
The predicted ISOT3 protein contains the conserved UBP catalytic sites and is 55% identical to ISOT. Northern blot analysis revealed that ISOT3 was expressed as 8.5-, 5.5-, and 3.5-kb mRNAs in all tissues tested, with the highest levels of expression observed in testis and ovary. The ISOT3 gene contains 20 exons and spans at least 90 kb. Since the exonic organization of ISOT and ISOT3 is highly conserved, with only 1 variant intron, the authors suggested that these 2 genes descended from a common ancestor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 13 (USP13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 13 (USP13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 13 (USP13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 13 (USP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 13 (USP13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 13 (USP13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 13 (USP13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 13 (USP13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 13 (USP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 13 (USP13) ELISA Kit Customized Service Offer
  1. "The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)."Gene 217:101-106(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Screen for ISG15-crossreactive deubiquitinases."PLoS ONE 2:E679-E679(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13."Cell 147:223-234(2011) [PubMed] [Europe PMC] [Abstract]
  10. "USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains."J. Biol. Chem. 286:27333-27341(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of MITF stability by the USP13 deubiquitinase."Nat. Commun. 2:414-414(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control."Proc. Natl. Acad. Sci. U.S.A. 108:9119-9124(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin."PLoS ONE 6:E29362-E29362(2011) [PubMed] [Europe PMC] [Abstract]