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Ubiquitin Specific Peptidase 14 (USP14)

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TGT; tRNA-Guanine Transglycosylase; Ubiquitin Specific Protease 14; Deubiquitinating enzyme 14; Ubiquitin carboxyl-terminal hydrolase 14

Ubiquitin Specific Peptidase 14 (USP14)
CCC F134
HGNC 12612
MGI 1928898
PubMed 24319254
RGD 1311825
UniProt P54578
Wiki USP14
Ubiquitin carboxyl-terminal hydrolase 14 is a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains.
This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF134Hu01 Recombinant Ubiquitin Specific Peptidase 14 (USP14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF134Hu21 Monoclonal Antibody to Ubiquitin Specific Peptidase 14 (USP14) WB; IHC; ICC; IP.
PAF134Hu01 Polyclonal Antibody to Ubiquitin Specific Peptidase 14 (USP14) WB; IHC; ICC; IP.
Assay Kits SEF134Hu ELISA Kit for Ubiquitin Specific Peptidase 14 (USP14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 14 (USP14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 14 (USP14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 14 (USP14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 14 (USP14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 14 (USP14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 14 (USP14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 14 (USP14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 14 (USP14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 14 (USP14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 14 (USP14) ELISA Kit Customized Service Offer
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  8. "USP14 inhibits ER-associated degradation via interaction with IRE1alpha."Biochem. Biophys. Res. Commun. 379:995-1000(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation."J. Biol. Chem. 284:5742-5752(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14."EMBO J. 24:3747-3756(2005) [PubMed] [Europe PMC] [Abstract]