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Ubiquitin Specific Peptidase 15 (USP15)

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UNPH4; Ubiquitin Specific Protease 15; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin carboxyl-terminal hydrolase 15

Ubiquitin Specific Peptidase 15 (USP15)
CCC F135
HGNC 12613
MGI 101857
PubMed 22344298
RGD 628795
UniProt Q9Y4E8
Wiki USP15
Ubiquitin , a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). By screening human brain cDNAs for those encoding proteins larger than 50 kD, Nagase et al. (1998) identified a partial cDNA encoding USP15, which they called KIAA0529. RT-PCR analysis detected USP15 expression in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues. The 952-amino acid USP15 protein contains the conserved cysteine and histidine boxes present in all USPs. Like USP4, USP15 can cleave the ubiquitin-proline bond.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 15 (USP15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 15 (USP15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 15 (USP15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 15 (USP15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 15 (USP15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 15 (USP15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 15 (USP15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 15 (USP15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 15 (USP15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 15 (USP15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 15 (USP15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 15 (USP15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 15 (USP15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 15 (USP15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 15 (USP15) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (JUL-2007) to UniProtKB
  7. "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases."Genomics 59:264-274(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation and characterization of the mouse ubiquitin-specific protease Usp15."Mamm. Genome 14:31-46(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1."Curr. Biol. 15:1217-1221(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha."EMBO J. 26:1532-1541(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP."J. Biol. Chem. 284:34944-34953(2009) [PubMed] [Europe PMC] [Abstract]
  15. "The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15."J. Mol. Biol. 391:691-702(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability."J. Virol. 83:8885-8892(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "USP15 is a deubiquitylating enzyme for receptor-activated SMADs."Nat. Cell Biol. 13:1368-1375(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  23. "USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma."Nat. Med. 18:429-435(2012) [PubMed] [Europe PMC] [Abstract]
  24. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  25. "The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination."J. Biol. Chem. 289:8916-8930(2014) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Solution structure of the human ubiquitin-specific protease 15 DUSP domain."J. Biol. Chem. 281:5026-5031(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Structure of the USP15 N-terminal domains: a beta-hairpin mediates close association between the DUSP and UBL domains."Biochemistry 50:7995-8004(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Structural variability of the ubiquitin specific protease DUSP-UBL double domains."FEBS Lett. 585:3385-3390(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of the human ubiquitin-specific protease 15 DUSP domain."Submitted (APR-2010) to the PDB data bank