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Xylosyltransferase I (XYLT1)

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XT-I; XT1; PXYLT1; Protein O Xylosyltransferase 1

Xylosyltransferase I (XYLT1)
CCC F141
HGNC 15516
MGI 2451073
PubMed 24161523
RGD 620093
UniProt Q86Y38
Wiki XYLT1
Xylosyltransferase (XT; EC 2.4.2.26) catalyzes the transfer of UDP-xylose to serine residues within XT recognition sequences of target proteins. A stable secondary structure assumed by XT1 mRNA prevented reverse transcription of the 5-prime untranslated region. The authors determined that the XT1 protein contains at least 827 amino acids and has a calculated molecular mass of at least 91 kD. It has 3 potential N-glycosylation sites and a DxD motif essential for binding nucleotide sugars in glycosyltransferases. Alignment of the XT1 and XT2 proteins with Xt1 and Xt2 from rat liver revealed highly conserved sequences in the central and C-terminal regions of the proteins. RT-PCR detected XT1 expression in all tissues examined, with highest levels in placenta, kidney, and pancreas, and lowest expression in skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF141Hu01 Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF141Hu01 Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
Assay Kits SEF141Hu ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF141Mu01 Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Xylosyltransferase I (XYLT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Xylosyltransferase I (XYLT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Xylosyltransferase I (XYLT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xylosyltransferase I (XYLT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Xylosyltransferase I (XYLT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Xylosyltransferase I (XYLT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Xylosyltransferase I (XYLT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Xylosyltransferase I (XYLT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xylosyltransferase I (XYLT1) ELISA Kit Customized Service Offer
  1. "Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity."Biochem. J. 386:227-236(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II."J. Mol. Biol. 304:517-528(2000) [PubMed] [Europe PMC] [Abstract]
  3. "First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells."J. Biol. Chem. 276:4940-4947(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis."J. Invest. Dermatol. 112:919-924(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Xylosyltransferase activity in seminal plasma of infertile men."Clin. Chim. Acta 317:199-202(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity."J. Biol. Chem. 279:42566-42573(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course."J. Med. Genet. 43:745-749(2006) [PubMed] [Europe PMC] [Abstract]
  8. "XYLT1 mutations in Desbuquois dysplasia type 2."Am. J. Hum. Genet. 94:405-414(2014) [PubMed] [Europe PMC] [Abstract]
  9. "The missing 'link': an autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation."Hum. Genet. 133:29-39(2014) [PubMed] [Europe PMC] [Abstract]