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Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1)

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GEMIN2; SIP1-delta; Gem-associated protein 2; Component of gems 2; SMN-interacting protein 1

Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1)
CCC F157
HGNC 10884
MGI 1913853
PubMed 23143680
RGD 620842
UniProt O14893
Wiki SIP1
SIP1 is expressed as a 1.3-kb transcript that encodes a 279-amino acid protein with a calculated molecular mass of 32 kD. Xenopus SIP1 is 90% identical to human SIP1 at the amino acid level. In addition, human SIP1 has significant identity with S. cerevisiae Brr1, which has been shown to be involved in snRNP biogenesis.
Liu et al. (1997) demonstrated that SMN and SIP1 interact tightly in vivo and in vitro and colocalize in gems in the nucleus as well as in the cytoplasm. Immunopurification of the 300-kD SMN-SIP1 complex showed that it contains, besides SMN and SIP1, spliceosomal snRNP core proteins. SMN interacted with several snRNP Sm core proteins and contains 2 distinct binding sites, one for SIP1 and one for the Sm proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Survival Of Motor Neuron Protein Interacting Protein 1 (SIP1) ELISA Kit Customized Service Offer
  1. "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins."Cell 90:1013-1021(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Increased expression level of the splicing variant of SIP1 in motor neuron diseases."Int. J. Biochem. Cell Biol. 34:699-707(2002) [PubMed] [Europe PMC] [Abstract]
  3. "An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA)."Eur. J. Hum. Genet. 8:493-499(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins."J. Biol. Chem. 277:5631-5636(2002) [PubMed] [Europe PMC] [Abstract]
  7. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]