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Death Associated Protein 3 (DAP3)

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MRP-S29; MRPS29; bMRP-10; 28S Ribosomal Protein S29,Mitochondrial; Ionizing radiation resistance conferring protein

Death Associated Protein 3 (DAP3)
CCC F165
HGNC 2673
MGI 1929538
PubMed 24300973
RGD 1305339
UniProt P51398
Wiki DAP3
DAP3 is transcribed into a 1.7-kb mRNA and encodes a 46-kD protein carrying a potential nucleotide-binding motif.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon.
DAP3 potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants that differ in the 5' UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF165Hu01 Recombinant Death Associated Protein 3 (DAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Death Associated Protein 3 (DAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Associated Protein 3 (DAP3) Polyclonal Antibody Customized Service Offer
Assay Kits SEF165Hu ELISA Kit for Death Associated Protein 3 (DAP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF165Mu01 Recombinant Death Associated Protein 3 (DAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Death Associated Protein 3 (DAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Associated Protein 3 (DAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Associated Protein 3 (DAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Associated Protein 3 (DAP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Death Associated Protein 3 (DAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Death Associated Protein 3 (DAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Associated Protein 3 (DAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Associated Protein 3 (DAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Associated Protein 3 (DAP3) ELISA Kit Customized Service Offer
  1. "The molecular genetics of human diseases with defective DNA damage processing."Thesis (1993), University of Stanford, United States
  2. "Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death."J. Biol. Chem. 270:27932-27936(1995) [PubMed] [Europe PMC] [Abstract]
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  8. "A conserved N-terminal sequence targets human DAP3 to mitochondria."Biochem. Biophys. Res. Commun. 280:177-181(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
  10. "hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis."J. Biol. Chem. 284:5414-5424(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction."Apoptosis 15:1247-1255(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]