≡

17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3)

[Edit]

SDR12C2; EDH17B3; Short Chain Dehydrogenase/Reductase Family 12C,Member 2; Testosterone 17-Beta-Dehydrogenase 3; Testicular 17-beta-hydroxysteroid dehydrogenase

17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3)
CCC F173
HGNC 5212
MGI 107177
PubMed 9709959
RGD 621805
UniProt P37058
Wiki HSD17B3
HSD17b3 is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
Geissler et al. (1994) used expression cloning to isolate cDNAs encoding a microsomal 17-beta-HSD type 3 isozyme that shares 23% sequence identity with other 17-beta-HSD enzymes, uses NADPH as a cofactor, and is expressed predominantly in the testes.Geissler et al. (1994) determined that the HSD17B3 gene spans at least 60 kb and consists of 11 exons, ranging in size from more than 264 bp to as small as 35 bp.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF173Hu01 Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Positive Control; Immunogen; SDS-PAGE; WB.
APF173Hu01 Active 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Cell culture; Activity Assays.
Antibodies PAF173Hu01 Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) WB; IHC; ICC; IP.
MAF173Hu21 Monoclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) WB; IHC; ICC; IP.
Assay Kits SEF173Hu ELISA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) CLIA Kit Customized Service Offer
n/a ELISA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Polyclonal Antibody Customized Service Offer
Assay Kits SEF173Ra ELISA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3."Nat. Genet. 7:34-39(1994) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency."J. Clin. Endocrinol. Metab. 81:130-136(1996) [PubMed] [Europe PMC] [Abstract]
  5. "A novel missense (R80W) mutation in 17-beta-hydroxysteroid dehydrogenase type 3 gene associated with male pseudohermaphroditism."Eur. J. Endocrinol. 139:330-333(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Deleterious missense mutations and silent polymorphism in the human 17beta-hydroxysteroid dehydrogenase 3 gene (HSD17B3)."J. Clin. Endocrinol. Metab. 83:2855-2860(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Substitution mutation C268Y causes 17 beta-hydroxysteroid dehydrogenase 3 deficiency."J. Clin. Endocrinol. Metab. 86:921-923(2001) [PubMed] [Europe PMC] [Abstract]