17-Beta-Hydroxysteroid Dehydrogenase Type 7 (HSD17b7)

The 17-beta-hydroxysteroid dehydrogenase enzyme oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.The deduced 341-amino acid protein is approximately 75% identical to the rodent proteins. It contains a 28-residue insert that forms a superficial loop close to the transmembrane domain. This loop is a candidate prolactin receptor (PRLR)-binding domain.

HSD17B7 gene contains 9 exons and spans approximately 22 kb. Promoter sequence analysis identified lymphoid- and brain-specific transcription factor-binding sites but no steroid-responsive elements, implying that an endocrine regulatory effect observed on Hsd17b7 in mouse may be indirect.