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11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2)

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AME; AME1; HSD11K; HSD2; SDR9C3; Short Chain Dehydrogenase/Reductase Family 9C,Member 3; NAD-dependent 11-beta-hydroxysteroid dehydrogenase

11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2)
CCC F183
HGNC 5209
MGI 104720
PubMed 12860834
RGD 2835
UniProt P80365
Wiki HSD11B2
Corticosteroid 11-beta-dehydrogenase isozyme 2 is an NAD+-dependent enzyme expressed in aldosterone-selective epithelial tissues such as the kidney, colon, salivary and sweat glands. HSD211B2 expression is also found in the brainstem in a small, aldosterone-sensitive subset of neurons located in the nucleus of the solitary tract.
In these tissues, HSD11B2 oxidizes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. This protective mechanism is necessary because cortisol circulates at 100-1000-fold higher concentrations than aldosterone, and binds with equal affinity to the mineralocorticoid receptor, thereby out-competing aldosterone in cells that do not produce HSD11B2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF183Hu01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF183Hu21 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) WB; IHC; ICC; IP.
PAF183Hu01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) WB; IHC; ICC; IP.
Assay Kits SEF183Hu ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF183Ra01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF183Ra21 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) WB; IHC; ICC; IP.
PAF183Ra01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) WB; IHC; ICC; IP.
Assay Kits SEF183Ra ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase."Genomics 29:195-199(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2."Biochem. J. 313:1007-1017(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Purification of 11 beta-hydroxysteroid dehydrogenase type 2 from human placenta utilizing a novel affinity labelling technique."Biochem. J. 313:997-1005(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Several homozygous mutations in the gene for 11 beta-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess."J. Clin. Endocrinol. Metab. 80:3145-3150(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age."Lancet 2:821-824(1987) [PubMed] [Europe PMC] [Abstract]
  8. "The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2."J. Biol. Chem. 276:28484-28492(2001) [PubMed] [Europe PMC] [Abstract]
  9. "A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess."J. Clin. Endocrinol. Metab. 80:2263-2266(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase."Nat. Genet. 10:394-399(1995) [PubMed] [Europe PMC] [Abstract]
  11. "A new compound heterozygous mutation in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess."J. Clin. Endocrinol. Metab. 82:4054-4058(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular basis for hypertension in the 'type II variant' of apparent mineralocorticoid excess."Am. J. Hum. Genet. 63:370-379(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess."J. Clin. Endocrinol. Metab. 83:2244-2254(1998) [PubMed] [Europe PMC] [Abstract]
  14. "The codon 213 of the 11beta-hydroxysteroid dehydrogenase type 2 gene is a hot spot for mutations in apparent mineralocorticoid excess."J. Clin. Endocrinol. Metab. 83:4391-4393(1998) [PubMed] [Europe PMC] [Abstract]
  15. "A genetic defect resulting in mild low-renin hypertension."Proc. Natl. Acad. Sci. U.S.A. 95:10200-10205(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Genetic, biochemical, and clinical studies of patients with A328V or R213C mutations in 11betaHSD2 causing apparent mineralocorticoid excess."Hypertension 34:435-441(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Mutants of 11beta-hydroxysteroid dehydrogenase (11-HSD2) with partial activity: improved correlations between genotype and biochemical phenotype in apparent mineralocorticoid excess."Hypertension 34:638-642(1999) [PubMed] [Europe PMC] [Abstract]
  18. "A mutation in the cofactor-binding domain of 11beta-hydroxysteroid dehydrogenase type 2 associated with mineralocorticoid hypertension."J. Clin. Endocrinol. Metab. 86:1247-1252(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Two homozygous mutations in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess."J. Clin. Endocrinol. Metab. 88:2501-2507(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess."J. Am. Soc. Nephrol. 18:1262-1270(2007) [PubMed] [Europe PMC] [Abstract]