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24-Dehydrocholesterol Reductase (DHCR24)

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Seladin-1; 3-beta-hydroxysterol delta-24-reductase; Diminuto/dwarf1 homolog

24-Dehydrocholesterol Reductase (DHCR24)
CCC F185
HGNC 2859
MGI 1922004
PubMed 22910610
RGD 1306529
UniProt Q15392
Wiki DHCR24
DHCR24is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 24-Dehydrocholesterol Reductase (DHCR24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 24-Dehydrocholesterol Reductase (DHCR24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 24-Dehydrocholesterol Reductase (DHCR24) Polyclonal Antibody Customized Service Offer
Assay Kits SEF185Hu ELISA Kit for 24-Dehydrocholesterol Reductase (DHCR24) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 24-Dehydrocholesterol Reductase (DHCR24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 24-Dehydrocholesterol Reductase (DHCR24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 24-Dehydrocholesterol Reductase (DHCR24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 24-Dehydrocholesterol Reductase (DHCR24) CLIA Kit Customized Service Offer
n/a ELISA Kit for 24-Dehydrocholesterol Reductase (DHCR24) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 24-Dehydrocholesterol Reductase (DHCR24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 24-Dehydrocholesterol Reductase (DHCR24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 24-Dehydrocholesterol Reductase (DHCR24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 24-Dehydrocholesterol Reductase (DHCR24) CLIA Kit Customized Service Offer
n/a ELISA Kit for 24-Dehydrocholesterol Reductase (DHCR24) ELISA Kit Customized Service Offer
  1. "The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress."J. Neurosci. 20:7345-7352(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in the 3beta-hydroxysterol delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis."Am. J. Hum. Genet. 69:685-694(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
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  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "The membrane topological analysis of 3 {beta}-hydroxysteroid-delta24 reductase (DHCR24) on endoplasmic reticulum."J. Mol. Endocrinol. 48:1-9(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]