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Alpha-1,3-Galactosyltransferase 1 (a3GALT1)

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ABO; A3GALNT; GTB; NAGAT; Histo-Blood Group ABO System Transferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase

Alpha-1,3-Galactosyltransferase 1 (a3GALT1)
CCC F189
HGNC 79
MGI 2135738
RGD 1311152
UniProt P16442
a3GALT1 encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene.This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-1,3-Galactosyltransferase 1 (a3GALT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1,3-Galactosyltransferase 1 (a3GALT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-1,3-Galactosyltransferase 1 (a3GALT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1,3-Galactosyltransferase 1 (a3GALT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-1,3-Galactosyltransferase 1 (a3GALT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-1,3-Galactosyltransferase 1 (a3GALT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1,3-Galactosyltransferase 1 (a3GALT1) ELISA Kit Customized Service Offer
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  2. "Molecular genetic basis of the histo-blood group ABO system."Nature 345:229-233(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic cloning of the human histo-blood group ABO locus."Biochem. Biophys. Res. Commun. 206:318-325(1995) [PubMed] [Europe PMC] [Abstract]
  4. ErratumBiochem. Biophys. Res. Commun. 211:347-347(1995) [PubMed] [Europe PMC] [Abstract]
  5. "A weak blood group A phenotype caused by a translation-initiator mutation in the ABO gene."Transfusion 46:434-440(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene."Transfusion 47:2330-2335(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Aberrant intracellular trafficking of a variant B glycosyltransferase."Transfusion 48:1898-1905(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The nature of diversity and diversification at the ABO locus."Blood 102:3035-3042(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular genetic analysis of variant phenotypes of the ABO blood group system."Blood 88:2732-2737(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Heterogeneity of the blood group Ax allele: genetic recombination of common alleles can result in the Ax phenotype."Transfus. Med. 8:231-238(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Evolution of the O alleles of the human ABO blood group gene."Transfusion 44:707-715(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Animal histo-blood group ABO genes."Biochem. Biophys. Res. Commun. 189:154-164(1992) [PubMed] [Europe PMC] [Abstract]
  14. "Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions."J. Biol. Chem. 265:19257-19262(1990) [PubMed] [Europe PMC] [Abstract]
  15. "The molecular basis for the B(A) allele: an amino acid alteration in the human histoblood group B alpha-(1,3)-galactosyltransferase increases its intrinsic alpha-(1,3)-N-acetylgalactosaminyltransferase activity."Biochem. Biophys. Res. Commun. 262:487-493(1999) [PubMed] [Europe PMC] [Abstract]
  16. "The structural basis for specificity in human ABO(H) blood group biosynthesis."Nat. Struct. Biol. 9:685-690(2002) [PubMed] [Europe PMC] [Abstract]
  17. "A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase."J. Biol. Chem. 278:12403-12405(2003) [PubMed] [Europe PMC] [Abstract]
  18. "The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases."J. Biol. Chem. 278:49191-49195(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Structural basis for the inactivity of human blood group O2 glycosyltransferase."J. Biol. Chem. 280:525-529(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Differential recognition of the type I and II H antigen acceptors by the human ABO(H) blood group A and B glycosyltransferases."J. Biol. Chem. 281:3625-3632(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif."J. Biol. Chem. 282:9564-9570(2007) [PubMed] [Europe PMC] [Abstract]