≡

Fucosyltransferase 2 (FUT2)

[Edit]

SE; Se2; Sej; Secretor Status Included; Galactoside 2-Alpha-L-Fucosyltransferase 2; Secretor blood group alpha-2-fucosyltransferase; Secretor factor

Fucosyltransferase 2 (FUT2)
CCC F192
HGNC 4013
MGI 109374
PubMed 18776911
RGD 2639
UniProt Q10981
Wiki FUT2
The classic human secretor locus (Se) FUT2 encodes alpha-(1,2)fucosyltransferase, which regulates expression of the Lewis ABO(H) histo-blood group antigens on the surface of epithelial cells and in body fluids and determines the secretion status of the ABO antigens. Secretor status of this polymorphic protein was used by Mohr (1951) to provide the first autosomal linkage in humans between secretor factor and the Lutheran blood group.
The secretor factor (Se) might be considered either a physiologic trait or an honorary blood group (VAM). The individual who is a so-called secretor has demonstrable ABH blood group antigen in the saliva and other body fluids; the nonsecretor does not. Secretor is dominant.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF192Hu01 Recombinant Fucosyltransferase 2 (FUT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fucosyltransferase 2 (FUT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fucosyltransferase 2 (FUT2) Polyclonal Antibody Customized Service Offer
Assay Kits SEF192Hu ELISA Kit for Fucosyltransferase 2 (FUT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fucosyltransferase 2 (FUT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fucosyltransferase 2 (FUT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fucosyltransferase 2 (FUT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fucosyltransferase 2 (FUT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fucosyltransferase 2 (FUT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fucosyltransferase 2 (FUT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fucosyltransferase 2 (FUT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fucosyltransferase 2 (FUT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fucosyltransferase 2 (FUT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fucosyltransferase 2 (FUT2) ELISA Kit Customized Service Offer
  1. "Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype."J. Biol. Chem. 270:4640-4649(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals."J. Biol. Chem. 271:9830-9837(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)."Eur. J. Biochem. 246:750-755(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency."Am. J. Hum. Genet. 59:343-350(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa."Hum. Genet. 103:204-210(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Common variants of FUT2 are associated with plasma vitamin B12 levels."Nat. Genet. 40:1160-1162(2008) [PubMed] [Europe PMC] [Abstract]