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Amine Oxidase, Copper Containing 2 (AOC2)

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RAO; DAO2; SSAO; Retina-specific copper amine oxidase; Semicarbazide-sensitive amine oxidase

Amine Oxidase, Copper Containing 2 (AOC2)
CCC F213
HGNC 549
MGI 2668431
PubMed 19588076
UniProt O75106
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. AOC2 shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals.
The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF213Hu01 Recombinant Amine Oxidase, Copper Containing 2 (AOC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Amine Oxidase, Copper Containing 2 (AOC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amine Oxidase, Copper Containing 2 (AOC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amine Oxidase, Copper Containing 2 (AOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amine Oxidase, Copper Containing 2 (AOC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amine Oxidase, Copper Containing 2 (AOC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amine Oxidase, Copper Containing 2 (AOC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amine Oxidase, Copper Containing 2 (AOC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amine Oxidase, Copper Containing 2 (AOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amine Oxidase, Copper Containing 2 (AOC2) ELISA Kit Customized Service Offer
  1. "Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping."Genomics 40:277-283(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human retina-specific amine oxidase: genomic structure of the gene (AOC2), alternatively spliced variant, and mRNA expression in retina."Genomics 51:293-298(1998) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "High expression of semicarbazide-sensitive amine oxidase genes AOC2 and AOC3, but not the diamine oxidase gene AOC1 in human adipocytes."Inflamm. Res. 52:S74-S75(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes."Biochimie 89:916-925(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase."Cell. Mol. Life Sci. 66:2743-2757(2009) [PubMed] [Europe PMC] [Abstract]