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Aurora Kinase A (AURKA)

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AIK; ARK1; AURA; AURORA2; BTAK; STK15; STK6; STK7; Aurora/IPL1-related kinase 1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 6

Aurora Kinase A (AURKA)
CCC F215
HGNC 11393
MGI 894678
PubMed 22621899
RGD 628895
UniProt O14965
Wiki AURKA
A is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF215Hu01 Recombinant Aurora Kinase A (AURKA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF215Hu01 Polyclonal Antibody to Aurora Kinase A (AURKA) WB; IHC; ICC; IP.
Assay Kits SEF215Hu ELISA Kit for Aurora Kinase A (AURKA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aurora Kinase A (AURKA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aurora Kinase A (AURKA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aurora Kinase A (AURKA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aurora Kinase A (AURKA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aurora Kinase A (AURKA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aurora Kinase A (AURKA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aurora Kinase A (AURKA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aurora Kinase A (AURKA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aurora Kinase A (AURKA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aurora Kinase A (AURKA) ELISA Kit Customized Service Offer
  1. "Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1."J. Biol. Chem. 272:13766-13771(1997) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2."Biochem. Biophys. Res. Commun. 244:285-292(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation."Nat. Genet. 20:189-193(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers."EMBO J. 17:3052-3065(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway."Oncogene 19:2812-2819(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation."Oncogene 19:4906-4916(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle."J. Biol. Chem. 276:46219-46224(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular dynamics of Aurora-A kinase in living mitotic cells simultaneously visualized with histone H3 and nuclear membrane protein importinalpha."Cell Struct. Funct. 27:457-467(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells."Genes Cells 7:1173-1182(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1."J. Biol. Chem. 277:10719-10726(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells."Cell 114:585-598(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells."J. Biol. Chem. 278:51786-51795(2003) [PubMed] [Europe PMC] [Abstract]
  15. "TACC1-chTOG-Aurora A protein complex in breast cancer."Oncogene 22:8102-8116(2003) [PubMed] [Europe PMC] [Abstract]
  16. "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase."Genes Cells 9:383-397(2004) [PubMed] [Europe PMC] [Abstract]
  17. "BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition."J. Biol. Chem. 279:19643-19648(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition."J. Cell Sci. 117:2523-2531(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53."Nat. Genet. 36:55-62(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1."Genes Cells 10:627-638(2005) [PubMed] [Europe PMC] [Abstract]
  21. "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A."Mol. Cell 20:237-249(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A."Mol. Cell. Biol. 25:5789-5800(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Mitotic activation of the kinase Aurora-A requires its binding partner Bora."Dev. Cell 11:147-157(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation."Cancer Res. 67:11186-11194(2007) [PubMed] [Europe PMC] [Abstract]
  25. "HEF1-dependent Aurora A activation induces disassembly of the primary cilium."Cell 129:1351-1363(2007) [PubMed] [Europe PMC] [Abstract]
  26. "GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases."Dev. Cell 12:699-712(2007) [PubMed] [Europe PMC] [Abstract]
  27. "Functional interaction of Aurora-A and PP2A during mitosis."Mol. Biol. Cell 18:1233-1241(2007) [PubMed] [Europe PMC] [Abstract]
  28. "Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis."PLoS ONE 2:E784-E784(2007) [PubMed] [Europe PMC] [Abstract]
  29. "Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase."Proc. Natl. Acad. Sci. U.S.A. 104:4106-4111(2007) [PubMed] [Europe PMC] [Abstract]
  30. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery."Nature 455:119-123(2008) [PubMed] [Europe PMC] [Abstract]
  32. "Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora A and regulates its function in neuronal polarity."J. Biol. Chem. 284:33571-33579(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a."J. Cell Sci. 122:1334-1341(2009) [PubMed] [Europe PMC] [Abstract]
  34. "An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics."Nat. Cell Biol. 11:1057-1068(2009) [PubMed] [Europe PMC] [Abstract]
  35. "A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function."Proc. Natl. Acad. Sci. U.S.A. 106:6939-6944(2009) [PubMed] [Europe PMC] [Abstract]
  36. "Pitchfork regulates primary cilia disassembly and left-right asymmetry."Dev. Cell 19:66-77(2010) [PubMed] [Europe PMC] [Abstract]
  37. "Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation."Int. J. Oncol. 37:429-436(2010) [PubMed] [Europe PMC] [Abstract]
  38. "Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase."J. Biol. Chem. 285:22196-22201(2010) [PubMed] [Europe PMC] [Abstract]
  39. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  40. "PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."Int. J. Oncol. 38:777-785(2011) [PubMed] [Europe PMC] [Abstract]
  41. "The cellular geography of aurora kinases."Nat. Rev. Mol. Cell Biol. 4:842-854(2003) [PubMed] [Europe PMC] [Abstract]
  42. "Aurora A, centrosome structure, and the centrosome cycle."Environ. Mol. Mutagen. 50:602-619(2009) [PubMed] [Europe PMC] [Abstract]
  43. "SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity."Cancer Cell 20:487-499(2011) [PubMed] [Europe PMC] [Abstract]
  44. "Furry protein promotes Aurora A-mediated polo-like kinase 1 activation."J. Biol. Chem. 287:27670-27681(2012) [PubMed] [Europe PMC] [Abstract]
  45. "Crystal structure of aurora-2, an oncogenic serine/threonine kinase."J. Biol. Chem. 277:42419-42422(2002) [PubMed] [Europe PMC] [Abstract]
  46. "Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography."Structure 10:1659-1667(2002) [PubMed] [Europe PMC] [Abstract]
  47. "Structural basis of Aurora-A activation by TPX2 at the mitotic spindle."Mol. Cell 12:851-862(2003) [PubMed] [Europe PMC] [Abstract]
  48. "SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors."Bioorg. Med. Chem. Lett. 16:1320-1323(2006) [PubMed] [Europe PMC] [Abstract]
  49. "1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile." J. Med. Chem. 49:7247-7251(2006) [PubMed] [Europe PMC] [Abstract]
  50. "Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2."Protein Sci. 17:1791-1797(2008) [PubMed] [Europe PMC] [Abstract]
  51. "A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2."J. Biol. Chem. 284:33177-33184(2009) [PubMed] [Europe PMC] [Abstract]
  52. "Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity."J. Med. Chem. 52:1050-1062(2009) [PubMed] [Europe PMC] [Abstract]
  53. "A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B." J. Med. Chem. 52:3300-3307(2009) [PubMed] [Europe PMC] [Abstract]
  54. "Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk."Cancer Res. 65:3548-3554(2005) [PubMed] [Europe PMC] [Abstract]
  55. "Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese."Yi Chuan Xue Bao 32:331-336(2005) [PubMed] [Europe PMC] [Abstract]
  56. "Aurora kinases A and B and familial breast cancer risk."Cancer Lett. 247:266-272(2007) [PubMed] [Europe PMC] [Abstract]
  57. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]