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Breast Carcinoma Amplified Sequence 3 (BCAS3)

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GAOB1; MAAB; GAOB1

Breast Carcinoma Amplified Sequence 3 (BCAS3)
CCC F221
HGNC 14347
MGI 2385848
PubMed 17505058
RGD 1560788
UniProt Q9H6U6
Wiki BCAS3
The BCAS3 gene is regulated by estrogen receptor alpha (ER-α). The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α. Furthermore BCAS3 requires PELP1 to function as a coactivator in ER-α. The deduced 913-amino acid protein has a calculated molecular mass of 99 kD. Northern blot analysis revealed a 3.9-kb transcript expressed in all tissues examined. Several smaller transcripts showed tissue-specific distribution. Multiple tissue expression array analysis indicated ubiquitous expression, with highest levels in stomach, liver, lung, kidney, fetal kidney, prostate, testis, thyroid gland, and adrenal gland.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF221Hu01 Recombinant Breast Carcinoma Amplified Sequence 3 (BCAS3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF221Hu01 Polyclonal Antibody to Breast Carcinoma Amplified Sequence 3 (BCAS3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Breast Carcinoma Amplified Sequence 3 (BCAS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Breast Carcinoma Amplified Sequence 3 (BCAS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Breast Carcinoma Amplified Sequence 3 (BCAS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Breast Carcinoma Amplified Sequence 3 (BCAS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Breast Carcinoma Amplified Sequence 3 (BCAS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Breast Carcinoma Amplified Sequence 3 (BCAS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Breast Carcinoma Amplified Sequence 3 (BCAS3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Breast Carcinoma Amplified Sequence 3 (BCAS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Breast Carcinoma Amplified Sequence 3 (BCAS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Breast Carcinoma Amplified Sequence 3 (BCAS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Breast Carcinoma Amplified Sequence 3 (BCAS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Breast Carcinoma Amplified Sequence 3 (BCAS3) ELISA Kit Customized Service Offer
  1. "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer."Genes Chromosomes Cancer 35:311-317(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "MTA1, a transcriptional activator of breast cancer amplified sequence 3."Proc. Natl. Acad. Sci. U.S.A. 103:6670-6675(2006) [PubMed] [Europe PMC] [Abstract]
  7. ErratumProc. Natl. Acad. Sci. U.S.A. 110:4147-4148(2013)
  8. "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)."Mol. Endocrinol. 21:1847-1860(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis."PLoS ONE 2:E1202-E1202(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis."Exp. Cell Res. 318:753-767(2012) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]