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Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D)

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CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3; Calcium channel, L type, alpha-1 polypeptide, isoform 2

Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D)
CCC F237
HGNC 1391
MGI 88293
PubMed 23913001
RGD 70973
UniProt Q01668
Wiki CACNA1D
On the basis of their kinetics and pharmacology, 4 types of Ca(2+) currents have been described. The Ca(2+) channel activity associated with the skeletal muscle, heart, and neuroendocrine/brain alpha-1 subunit isoforms is inhibited by dihydropyridine (DHP) drugs, indicating that these represent L-type currents. By contrast, the activity of the brain isoform is not inhibited by dihydropyridine drugs and thus may represent a P-type current.
CACNA1D, the deduced 2,161-amino acid protein has a calculated molecular mass of 245 kD. The predicted structure consists of 4 repeating domains, each comprising 5 hydrophobic segments. There was evidence of alternative splicing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF237Hu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF237Hu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
MAF237Hu21 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
Assay Kits SEF237Hu ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF237Mu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
RPF237Mu02 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF237Mu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAF237Mu02 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
Assay Kits SEF237Mu ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) ELISA Kit Customized Service Offer
  1. "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype."Neuron 8:71-84(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells."Proc. Natl. Acad. Sci. U.S.A. 89:584-588(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes."Genomics 27:312-319(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain."J. Biol. Chem. 283:20733-20744(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic structure of the regulatory region of the voltage-gated calcium channel alpha 1D."Exp. Mol. Med. 30:246-251(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma."Mayo Clin. Proc. 67:1150-1159(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide."Protein Sci. 20:278-290(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness."Nat. Neurosci. 14:77-84(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism." Nat. Genet. 45:1050-1054(2013) [PubMed] [Europe PMC] [Abstract]