Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B)

Voltage-dependent Ca(2+) channels are multisubunit complexes found in the membrane of many excitable cells that regulate calcium entry. N-type calcium channels, which control neurotransmitter release from neurons, are dihydropyridine-insensitive and omega-conotoxin-sensitive.

CACNA1B form a macromolecular complex. Functional studies in Xenopus oocytes indicated that expression of ENH resulted in increased rapid and specific modulation of N-type calcium channels by PKCE. The authors concluded that through interactions with a common adaptor protein, the formation of a kinase-substrate complex is the molecular basis for the specificity and efficiency of cellular signaling.