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Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4)

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CAB4; CACNLB4; EA5; EJM4; Calcium channel voltage-dependent subunit beta 4

Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4)
CCC F253
HGNC 1404
MGI 103301
PubMed 22892567
RGD 68385
UniProt O00305
Wiki CACNB4
CACNb4 is a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing.
The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Beta 4 Subunit (CACNb4) ELISA Kit Customized Service Offer
  1. "Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23."Hum. Genet. 100:151-154(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing of the beta 4 subunit has alpha 1 subunit subtype-specific effects on Ca2+ channel gating."J. Neurosci. 22:1573-1582(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The GK domain of the voltage-dependent calcium channel beta subunit is essential for binding to the alpha subunit."Biochem. Biophys. Res. Commun. 360:679-683(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Calcium channel beta4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic."Genomics 50:14-22(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia."Am. J. Hum. Genet. 66:1531-1539(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]