Calcium Dependent Secretion Activator 2 (CADPS2)

CADPS2 is a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility.

CADPS2 shares 80% amino acid identity with CADPS and 90% identity with mouse Cadps2. Northern blot analysis detected a 5.0-kb transcript in all adult and fetal tissues examined. Within specific brain regions, highest expression was detected in cerebellum, with lower expression in cerebral cortex, occipital pole, and frontal and temporal lobes, and weak expression in medulla, spinal cord, and putamen. A faint 5.2-kb transcript was also present in medulla.