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Carbonyl Reductase 3 (CBR3)

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SDR21C2; Short Chain Dehydrogenase/Reductase Family 21C,Member 2; NADPH-dependent carbonyl reductase 3

Carbonyl Reductase 3 (CBR3)
CCC F264
HGNC 1549
MGI 1309992
PubMed 20806931
RGD 1309728
UniProt O75828
Wiki CBR3
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. Carbonyl reductase (CBR) catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. By analyzing sequences from the 21q22.2 chromosomal region, Watanabe et al. (1998) identified genomic clones corresponding to CBR1 and to CBR3, a novel carbonyl reductase gene. The deduced 277-amino acid CBR3 protein is 84% similar to the CBR1 protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF264Hu01 Recombinant Carbonyl Reductase 3 (CBR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF264Hu01 Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) WB; IHC; ICC; IP.
MAF264Hu21 Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) WB; IHC; ICC; IP.
Assay Kits SEF264Hu ELISA Kit for Carbonyl Reductase 3 (CBR3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbonyl Reductase 3 (CBR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbonyl Reductase 3 (CBR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonyl Reductase 3 (CBR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbonyl Reductase 3 (CBR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbonyl Reductase 3 (CBR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonyl Reductase 3 (CBR3) ELISA Kit Customized Service Offer
  1. "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2."Genomics 52:95-100(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1."Mol. Cell. Biochem. 315:113-121(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of human carbonyl reductase 3, complexed with NADP+."Submitted (FEB-2009) to the PDB data bank
  7. "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)."Drug Metab. Dispos. 33:254-257(2005) [PubMed] [Europe PMC] [Abstract]