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Tight Junction Protein 3 (TJP3)

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ZO-3; Zona Occludens 3; Zonula occludens protein 3

Tight Junction Protein 3 (TJP3)
CCC F268
HGNC 11829
MGI 1351650
PubMed 18275946
RGD 1309247
UniProt O95049
Wiki TJP3
TJP3 is a member of the family of membrane-associated guanylate kinase-like proteins (MAGUK) that associate with intracellular junctions.Using a peptide sequence derived from a 130-kD protein that coimmunoprecipitated with TJP1 in canine kidney cells, Haskins et al. (1998) isolated canine Tjp3, which they called ZO3. The deduced 898-amino acid protein has a predicted molecular mass of 98 kD, although it runs anomalously at 130 kD by SDS PAGE. Canine Tjp3 shares 47% amino acid identity with human TJP1 and TJP2. The Tjp3 protein contains 3 PDZ domains, an SH3 domain, and a guanylate kinase (GUK) domain with high similarity to TJP1 and TJP2, as well as a unique proline-rich region between PDZ2 and PDZ3. Immunogold electro microscopy localized TJP3 with TJP1 to tight junctions in canine kidney cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF268Hu01 Recombinant Tight Junction Protein 3 (TJP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF268Hu01 Polyclonal Antibody to Tight Junction Protein 3 (TJP3) WB; IHC; ICC; IP.
Assay Kits SEF268Hu ELISA Kit for Tight Junction Protein 3 (TJP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tight Junction Protein 3 (TJP3) Recombinant Protein Customized Service Offer
Antibodies PAF268Mu01 Polyclonal Antibody to Tight Junction Protein 3 (TJP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tight Junction Protein 3 (TJP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tight Junction Protein 3 (TJP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF268Ra01 Recombinant Tight Junction Protein 3 (TJP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF268Ra01 Polyclonal Antibody to Tight Junction Protein 3 (TJP3) WB; IHC; ICC; IP.
Assay Kits SEF268Ra ELISA Kit for Tight Junction Protein 3 (TJP3) Enzyme-linked immunosorbent assay for Antigen Detection.
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  11. "Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form."Submitted (NOV-2009) to the PDB data bank