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Centrosomal Protein 57kDa (CEP57)

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PIG8; TSP57; Translokin; FGF2-interacting protein; Testis-specific protein 57

Centrosomal Protein 57kDa (CEP57)
CCC F269
HGNC 30794
MGI 1915551
PubMed 21552266
RGD 1309884
UniProt Q86XR8
Wiki CEP57
Translokin binds basic fibroblast growth factor (FGF2) and mediates its nuclear translocation and mitogenic activity. The deduced 474-amino acid protein contains transmembrane domains and shares about 17% identity with smooth muscle myosin (MYH11). The deduced 500-amino acid protein shares about 88% sequence identity with the mouse and bovine homologs. Other transcripts of about 2.6 and 2.2 kb were expressed at highest levels in heart and skeletal muscle, with lowest levels in lung. RT-PCR and Western blot analysis detected expression in all cell lines examined. The translokin protein showed an apparent molecular mass of about 55 kD. Epitope-tagged translokin localized to the cytoplasm of transfected COS-7 cells in a distribution that completely overlapped with microtubules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF269Hu01 Recombinant Centrosomal Protein 57kDa (CEP57) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 57kDa (CEP57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 57kDa (CEP57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 57kDa (CEP57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 57kDa (CEP57) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF269Mu01 Recombinant Centrosomal Protein 57kDa (CEP57) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 57kDa (CEP57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 57kDa (CEP57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 57kDa (CEP57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 57kDa (CEP57) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 57kDa (CEP57) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 57kDa (CEP57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 57kDa (CEP57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 57kDa (CEP57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 57kDa (CEP57) ELISA Kit Customized Service Offer
  1. "Translokin is an intracellular mediator of FGF-2 trafficking."Nat. Cell Biol. 5:433-439(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Proteomic characterization of the human centrosome by protein correlation profiling."Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in CEP57 cause mosaic variegated aneuploidy syndrome." Nat. Genet. 43:527-529(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]