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Centrosomal Protein 135kDa (CEP135)

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CEP4; Centrosomal Protein 4

Centrosomal Protein 135kDa (CEP135)
CCC F273
HGNC 29086
MGI 2681869
PubMed 22521416
RGD 1310726
UniProt Q66GS9
Wiki CEP135
The transcript contains repetitive elements at both the 5-prime and 3-prime UTRs, and the deduced protein contains 846 amino acids. RT-PCR detected variable CEP135 expression in all tissues examined, with highest expression in kidney, testis, and ovary, and lowest expression in brain and spleen. CEP135, PLK4, SAS6, CPAP (CENPJ), TUBG1, and CP110 were required at different stages of procentriole formation and were associated with different centriolar structures. SAS6 associated only transiently with nascent procentrioles, whereas CEP135 and CPAP formed a core structure within the proximal lumen of both parental and nascent centrioles. The predicted molecular mass was 135 kD. Imaging confirmed that fluorescence- and epitope-tagged CEP135 localized to centrosomes in a human osteoblastoma cell line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 135kDa (CEP135) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 135kDa (CEP135) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 135kDa (CEP135) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 135kDa (CEP135) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 135kDa (CEP135) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 135kDa (CEP135) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 135kDa (CEP135) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 135kDa (CEP135) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 135kDa (CEP135) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 135kDa (CEP135) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 135kDa (CEP135) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 135kDa (CEP135) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 135kDa (CEP135) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 135kDa (CEP135) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 135kDa (CEP135) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Proteomic characterization of the human centrosome by protein correlation profiling."Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Plk4-induced centriole biogenesis in human cells."Dev. Cell 13:190-202(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization."Exp. Cell Res. 314:3692-3700(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function."Am. J. Hum. Genet. 90:871-878(2012) [PubMed] [Europe PMC] [Abstract]