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Choline Kinase Beta (CHKb)

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CHETK; CHKL; CKEKB; Choline Kinase Like; choline/ethanolamine kinase beta

Choline Kinase Beta (CHKb)
CCC F284
HGNC 1938
MGI 1328313
PubMed 18820697
RGD 61826
UniProt Q9Y259
Wiki CHKB
Choline kinase beta is a protein found on chromosome 22 in humans.Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine.
This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF284Hu01 Recombinant Choline Kinase Beta (CHKb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Choline Kinase Beta (CHKb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Kinase Beta (CHKb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Kinase Beta (CHKb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Kinase Beta (CHKb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF284Mu01 Recombinant Choline Kinase Beta (CHKb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Choline Kinase Beta (CHKb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Kinase Beta (CHKb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Kinase Beta (CHKb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Kinase Beta (CHKb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Choline Kinase Beta (CHKb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Choline Kinase Beta (CHKb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Kinase Beta (CHKb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Kinase Beta (CHKb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Kinase Beta (CHKb) ELISA Kit Customized Service Offer
  1. "Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I."J. Biol. Chem. 275:31739-31746(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAY-2006) to UniProtKB
  7. "Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment."PLoS ONE 4:E7819-E7819(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide."Submitted (SEP-2009) to the PDB data bank