Staphylococcal Nuclease Domain Containing Protein 1 (SND1)

Epstein-Barr virus (EBV) nuclear antigen-2 (EBNA2) activates transcription of specific genes and is essential for EBV-mediated B-lymphocyte transformation. Tong et al. (1995) showed that EBNA2 binds to the nuclear protein p100 and that p100 coactivates gene expression mediated by the EBNA2 acidic domain. Using affinity cloning, Tong et al. (1995) cloned the human p100 gene and showed that it encodes an 885-amino acid polypeptide that contains 2 potential nuclear localization signals. By Northern blotting, p100 appeared to be ubiquitously expressed. The p100 protein also binds both the p56 and p34 subunits of transcription factor IIE .Callebaut and Mornon (1997) identified a novel domain within the p100 sequence that they named the 'tudor domain' because it is present in multiple copies in the Drosophila 'tudor' protein.