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Calcium And Integrin Binding Protein 2 (CIB2)

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KIP2; Kinase-interacting protein 2

Calcium And Integrin Binding Protein 2 (CIB2)
CCC F288
HGNC 24579
MGI 1929293
PubMed 23023331
RGD 1308718
UniProt O75838
The amino acid sequence the protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the encoded protein may be a Ca2+-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
KIP2 encodes a deduced 187-amino acid protein with a predicted molecular mass of 22 kD. The KIP2 protein shares 46%, 39%, and 30% sequence identity with the calcium-binding proteins KIP/CIB, calcineurin B, and calmodulin, respectively. Sequence analysis of KIP2 revealed 2 EF-hand motifs and a helix-loop-helix motif involved in coordinating the calcium ion, indicating that KIP2 may also bind calcium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF288Hu01 Recombinant Calcium And Integrin Binding Protein 2 (CIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Calcium And Integrin Binding Protein 2 (CIB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium And Integrin Binding Protein 2 (CIB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium And Integrin Binding Protein 2 (CIB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium And Integrin Binding Protein 2 (CIB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium And Integrin Binding Protein 2 (CIB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium And Integrin Binding Protein 2 (CIB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium And Integrin Binding Protein 2 (CIB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium And Integrin Binding Protein 2 (CIB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium And Integrin Binding Protein 2 (CIB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium And Integrin Binding Protein 2 (CIB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium And Integrin Binding Protein 2 (CIB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium And Integrin Binding Protein 2 (CIB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium And Integrin Binding Protein 2 (CIB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium And Integrin Binding Protein 2 (CIB2) ELISA Kit Customized Service Offer
  1. "Structure, expression profile and chromosomal location of an isolog of DNA-PKcs interacting protein (KIP) gene."Biochim. Biophys. Acta 1444:143-147(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences."Biochem. Cell Biol. 90:646-656(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48." Nat. Genet. 44:1265-1271(2012) [PubMed] [Europe PMC] [Abstract]