Cytokine Receptor Like Factor 2 (CRLF2)

Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.

Sequence analysis predicted that the 371-amino acid type I transmembrane protein contains an N-terminal signal peptide, 4 potential N-linked glycosylation sites, 2 of 4 conserved cysteine residues, and a PSDWS sequence in place of the hallmark WSXWS motif. CRLF2 also has a transmembrane domain and a 119-amino acid intracellular domain with a conserved membrane-proximal 'box 1' motif and a potential signal-transducing tyrosine residue.