≡

Carboxypeptidase A2, Pancreatic (CPA2)

[Edit]

Carboxypeptidase A2, Pancreatic (CPA2)
CCC F316
HGNC 2297
MGI 3617840
PubMed 7896805
RGD 1305563
UniProt P48052
Wiki CPA2
Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues. The full-length cDNA encodes a deduced 417-amino acid protein, which includes a short leader sequence and a 94-amino acid long activation segment.
The human CPA2 protein shares 89% similarity with the rat CPA2 protein and 64% similarity with human CPA1. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues, in contrast to the A1 form, which shows a preference for the aliphatic C-terminal residues of peptide substrates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF316Ra01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF316Ra01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
MAF316Ra21 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
Assay Kits SEF316Ra ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model."J. Biol. Chem. 270:6651-6657(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2."Arch. Biochem. Biophys. 332:8-18(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and properties of five different forms of human procarboxypeptidases."Eur. J. Biochem. 179:609-616(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography."Biomed. Chromatogr. 7:143-145(1993) [PubMed] [Europe PMC] [Abstract]
  8. "The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen."EMBO J. 16:6906-6913(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2."FEBS Lett. 420:7-10(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2."Nat. Struct. Biol. 7:322-328(2000) [PubMed] [Europe PMC] [Abstract]
  11. "A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins."J. Mol. Biol. 332:449-460(2003) [PubMed] [Europe PMC] [Abstract]
  12. "NMR solution structure of the activation domain of human procarboxypeptidase A2."Protein Sci. 12:296-305(2003) [PubMed] [Europe PMC] [Abstract]