≡

Carboxypeptidase A4 (CPA4)

[Edit]

Carboxypeptidase A4 (CPA4)
CCC F317
HGNC 15740
MGI 1919041
PubMed 10383164
RGD 1563619
UniProt Q9UI42
Wiki CPA4
Carboxypeptidase A4 is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. The deduced 421-amino acid CPA4 protein contains 2 zinc-binding signature domains of metallocarboxypeptidases and a 16-amino acid N-terminal signal peptide. The protein shares 63% and 61% sequence identity with human and rat CPA2, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF317Hu01 Recombinant Carboxypeptidase A4 (CPA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF317Hu01 Polyclonal Antibody to Carboxypeptidase A4 (CPA4) WB
MAF317Hu21 Monoclonal Antibody to Carboxypeptidase A4 (CPA4) WB; IHC; ICC; IP.
Assay Kits SEF317Hu ELISA Kit for Carboxypeptidase A4 (CPA4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase A4 (CPA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase A4 (CPA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase A4 (CPA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase A4 (CPA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase A4 (CPA4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase A4 (CPA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase A4 (CPA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase A4 (CPA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase A4 (CPA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase A4 (CPA4) ELISA Kit Customized Service Offer
  1. "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells."Cancer Res. 59:2981-2988(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain."Hum. Genet. 112:220-226(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing."J. Biol. Chem. 285:18385-18396(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin."Cell. Mol. Life Sci. 62:1996-2014(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin."Proc. Natl. Acad. Sci. U.S.A. 102:3978-3983(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4."J. Biol. Chem. 287:9250-9258(2012) [PubMed] [Europe PMC] [Abstract]