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Carboxypeptidase B1, Tissue (CPB1)

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CPB; PCPB; PASP; Pancreas-specific protein

Carboxypeptidase B1, Tissue (CPB1)
CCC F320
HGNC 2299
MGI 1923953
PubMed 23569111
RGD 2391
UniProt P15086
Wiki CPB
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma.
The deduced 416-amino acid preproenzyme (EC 3.4.17.2) has a 15-amino acid signal peptide and a 95-amino acid activation peptide. It shares 76% and 84% sequence identity with the rat and bovine homologs, respectively. DNA blot analysis indicated that the PCPB mRNA is transcribed from a single locus. Northern blot analysis demonstrated pancreas-specific expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF320Hu01 Recombinant Carboxypeptidase B1, Tissue (CPB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF320Hu01 Polyclonal Antibody to Carboxypeptidase B1, Tissue (CPB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Carboxypeptidase B1, Tissue (CPB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase B1, Tissue (CPB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF320Mu01 Recombinant Carboxypeptidase B1, Tissue (CPB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF320Mu01 Polyclonal Antibody to Carboxypeptidase B1, Tissue (CPB1) WB; IHC; ICC; IP.
Assay Kits SEF320Mu ELISA Kit for Carboxypeptidase B1, Tissue (CPB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF320Ra01 Recombinant Carboxypeptidase B1, Tissue (CPB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF320Ra01 Polyclonal Antibody to Carboxypeptidase B1, Tissue (CPB1) WB; IHC; ICC; IP.
MAF320Ra21 Monoclonal Antibody to Carboxypeptidase B1, Tissue (CPB1) WB; IHC; ICC; IP.
Assay Kits SEF320Ra ELISA Kit for Carboxypeptidase B1, Tissue (CPB1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B."J. Biol. Chem. 267:2575-2581(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B."Biol. Chem. 379:149-155(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Purification and properties of five different forms of human procarboxypeptidases."Eur. J. Biochem. 179:609-616(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI)."J. Mol. Biol. 321:537-547(2002) [PubMed] [Europe PMC] [Abstract]