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Complexin 2 (CPLX2)

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921-L; CPX-2; CPX2; Synaphin-1

Complexin 2 (CPLX2)
CCC F332
HGNC 2310
MGI 104726
PubMed 23912489
RGD 70945
UniProt Q6PUV4
Wiki CPLX2
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.
Sequence analysis determined that the rat Cplx1 and Cplx2 genes encode 134-amino acid, highly charged proteins that share 84% amino acid identity. Asp, glu, lys, and arg account for 44 to 47% of the complexin protein residues. The amino acid sequences, but not the nucleotide sequences, of mouse, rat, and human CPLX2 are 100% identical.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF332Hu01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF332Hu01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
MAF332Hu21 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
Assay Kits SEF332Hu ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection.
CEF332Hu ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF332Mu01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF332Mu01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complexin 2 (CPLX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complexin 2 (CPLX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complexin 2 (CPLX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complexin 2 (CPLX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complexin 2 (CPLX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complexin 2 (CPLX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complexin 2 (CPLX2) ELISA Kit Customized Service Offer
  1. "Complexins: cytosolic proteins that regulate SNAP receptor function."Cell 83:111-119(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity."Gene 359:127-137(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia."Lancet 352:1669-1673(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins."Brain Res. Bull. 55:569-578(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Cerebellar synaptic protein expression in schizophrenia."Neuroscience 105:219-229(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements."J. Neurocytol. 33:517-533(2004) [PubMed] [Europe PMC] [Abstract]