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Crystallin Beta B2 (CRYbB2)

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CCA2; CRYB2; CRYB2A; Beta-crystallin Bp

Crystallin Beta B2 (CRYbB2)
CCC F346
HGNC 2398
MGI 88519
PubMed 22846113
RGD 2417
UniProt P43320
Wiki CRYBB2
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. CRYbB2, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF346Hu01 Recombinant Crystallin Beta B2 (CRYbB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Crystallin Beta B2 (CRYbB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Beta B2 (CRYbB2) Polyclonal Antibody Customized Service Offer
Assay Kits SEF346Hu ELISA Kit for Crystallin Beta B2 (CRYbB2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF346Mu01 Recombinant Crystallin Beta B2 (CRYbB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF346Mu01 Polyclonal Antibody to Crystallin Beta B2 (CRYbB2) WB; IHC; ICC; IP.
LAF346Mu71 Biotin-Linked Polyclonal Antibody to Crystallin Beta B2 (CRYbB2) WB; IHC; ICC.
Assay Kits SEF346Mu ELISA Kit for Crystallin Beta B2 (CRYbB2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF346Ra01 Recombinant Crystallin Beta B2 (CRYbB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF346Ra21 Monoclonal Antibody to Crystallin Beta B2 (CRYbB2) WB; IHC; ICC; IP.
PAF346Ra01 Polyclonal Antibody to Crystallin Beta B2 (CRYbB2) WB
Assay Kits SEF346Ra ELISA Kit for Crystallin Beta B2 (CRYbB2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Sequence of the human lens beta B2-crystallin-encoding cDNA."Gene 133:295-299(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2."Hum. Mol. Genet. 6:665-668(1997) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Two-dimensional gel electrophoretic analysis of human lens proteins."Curr. Eye Res. 11:669-677(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Post-translational modifications of water-soluble human lens crystallins from young adults."J. Biol. Chem. 269:12494-12502(1994) [PubMed] [Europe PMC] [Abstract]
  10. "The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage."Exp. Eye Res. 71:195-207(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic heterogeneity of the Coppock-like cataract: a mutation in CRYBB2 on chromosome 22q11.2."Invest. Ophthalmol. Vis. Sci. 41:159-165(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Mutation of interfaces in domain-swapped human betaB2-crystallin."Protein Sci. 16:615-625(2007) [PubMed] [Europe PMC] [Abstract]