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C-Terminal Binding Protein 2 (CTBP2)

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Ribeye

C-Terminal Binding Protein 2 (CTBP2)
CCC F359
HGNC 2495
MGI 1201686
PubMed 16999872
RGD 68372
UniProt P56545
Wiki CTBP2
CTBP2 produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression By similarity. Interacts with PNN, NRIP1 and WIZ

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF359Hu01 Recombinant C-Terminal Binding Protein 2 (CTBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF359Hu01 Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2) WB; IHC; ICC; IP.
MAF359Hu21 Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2) WB; IHC; ICC; IP.
Assay Kits SEF359Hu ELISA Kit for C-Terminal Binding Protein 2 (CTBP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Terminal Binding Protein 2 (CTBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Terminal Binding Protein 2 (CTBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Terminal Binding Protein 2 (CTBP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Terminal Binding Protein 2 (CTBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Terminal Binding Protein 2 (CTBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Terminal Binding Protein 2 (CTBP2) ELISA Kit Customized Service Offer
  1. "A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3."Genomics 47:294-299(1998) [PubMed] [Europe PMC] [Abstract]
  2. "RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function."Neuron 28:857-872(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation."Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene."Mol. Cell. Biol. 24:10223-10235(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)."Submitted (FEB-2009) to the PDB data bank