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Cullin 9 (CUL9)

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PARC; H7AP1; P53-Associated Parkin-Like Cytoplasmic Protein; UbcH7-associated protein 1

Cullin 9 (CUL9)
CCC F360
HGNC 15982
MGI 1925559
PubMed 21487039
RGD 1562008
UniProt Q8IWT3
PARC directly interacted and formed an approximately 1-MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53-dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53.abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines; RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.PARC also has a unique motif that is highly homologous to the C terminus of cullin proteins that the authors referred to as the C-terminal cullin homology domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF360Hu01 Recombinant Cullin 9 (CUL9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF360Hu21 Monoclonal Antibody to Cullin 9 (CUL9) WB; IHC; ICC; IP.
PAF360Hu01 Polyclonal Antibody to Cullin 9 (CUL9) WB; IHC; ICC; IP.
Assay Kits SEF360Hu ELISA Kit for Cullin 9 (CUL9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 9 (CUL9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 9 (CUL9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 9 (CUL9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 9 (CUL9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 9 (CUL9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 9 (CUL9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 9 (CUL9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 9 (CUL9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 9 (CUL9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 9 (CUL9) ELISA Kit Customized Service Offer
  1. "Parc: a cytoplasmic anchor for p53."Cell 112:29-40(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1."J. Biol. Chem. 274:30963-30968(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development."Mol. Cell. Biol. 25:5579-5589(2005) [PubMed] [Europe PMC] [Abstract]
  9. "PARC and CUL7 form atypical cullin RING ligase complexes."Cancer Res. 67:2006-2014(2007) [PubMed] [Europe PMC] [Abstract]
  10. "CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity."Mol. Cell 54:805-819(2014) [PubMed] [Europe PMC] [Abstract]