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Cullin 7 (CUL7)

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Cullin 7 (CUL7)
CCC F361
HGNC 21024
MGI 1913765
PubMed 18498745
RGD 1587048
UniProt Q14999
Wiki CUL7
Nomura et al. (1994) cloned CUL7, which they designated KIAA0076. The deduced 1,698-amino acid protein contains an ATP/GTP-binding site motif A and motifs found in mitochondrial energy transfer proteins. Northern blot analysis detected CUL7 expression in all tissues and cell lines tested except testis and small intestine.
By immunoprecipitating proteins that interacted with epitope-tagged ROC1 (RBX1) in human embryonic kidney cells, Dias et al. (2002) identified CUL7. The N-terminal half of CUL7 contains a 72-amino acid domain enriched in glycine and acidic residues that is similar to a corresponding region in HERC2. CUL7 also has a central DOC domain and a C-terminal cullin domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 7 (CUL7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 7 (CUL7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 7 (CUL7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 7 (CUL7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 7 (CUL7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 7 (CUL7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 7 (CUL7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 7 (CUL7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 7 (CUL7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 7 (CUL7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 7 (CUL7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 7 (CUL7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 7 (CUL7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 7 (CUL7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 7 (CUL7) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex."Proc. Natl. Acad. Sci. U.S.A. 99:16601-16606(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis."Proc. Natl. Acad. Sci. U.S.A. 100:9855-9860(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation."J. Virol. 79:11685-11692(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development."Mol. Cell. Biol. 25:5579-5589(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function."Oncogene 25:4534-4548(2006) [PubMed] [Europe PMC] [Abstract]
  10. "PARC and CUL7 form atypical cullin RING ligase complexes."Cancer Res. 67:2006-2014(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: new population isolate in Asia."J. Med. Genet. 44:772-778(2007) [PubMed] [Europe PMC] [Abstract]
  12. "The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation."Mol. Cell 30:403-414(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Exome sequencing identifies CCDC8 mutations in 3-M syndrome, Suggesting that CCDC8 Contributes in a Pathway with CUL7 and OBSL1 to Control Human Growth."Am. J. Hum. Genet. 89:148-153(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning."PLoS Biol. 9:E1001060-E1001060(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells."J. Biol. Chem. 285:10870-10879(2010) [PubMed] [Europe PMC] [Abstract]
  19. "The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1."J. Biol. Chem. 289:4009-4017(2014) [PubMed] [Europe PMC] [Abstract]
  20. "The 3M complex maintains microtubule and genome integrity."Mol. Cell 54:791-804(2014) [PubMed] [Europe PMC] [Abstract]
  21. "CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity."Mol. Cell 54:805-819(2014) [PubMed] [Europe PMC] [Abstract]
  22. "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53."J. Biol. Chem. 282:11300-11307(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Identification of mutations in CUL7 in 3-M syndrome." Nat. Genet. 37:1119-1124(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling." J. Mol. Endocrinol. 49:267-275(2012) [PubMed] [Europe PMC] [Abstract]