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Cullin 4B (CUL4B)

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Cullin 4B (CUL4B)
CCC F366
HGNC 2555
MGI 1919834
PubMed 23357576
RGD 1564494
UniProt Q13620
Wiki CUL4B
Cullin-4B is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.
Complex assembly and ubiquitin ligase activity of CUL4B(AHR) in vitro and in vivo are dependent on the AHR ligand. In the CUL4B(AHR) complex, ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 4B (CUL4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 4B (CUL4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 4B (CUL4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 4B (CUL4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 4B (CUL4B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 4B (CUL4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 4B (CUL4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 4B (CUL4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 4B (CUL4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 4B (CUL4B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 4B (CUL4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 4B (CUL4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 4B (CUL4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 4B (CUL4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 4B (CUL4B) ELISA Kit Customized Service Offer
  1. "Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint."Nat. Cell Biol. 5:1008-1015(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  8. "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family."Cell 85:829-839(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Covalent modification of all members of human cullin family proteins by NEDD8."Oncogene 18:6829-6834(1999) [PubMed] [Europe PMC] [Abstract]
  10. "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity."Mol. Cell 3:535-541(1999) [PubMed] [Europe PMC] [Abstract]
  11. "TIP120A associates with cullins and modulates ubiquitin ligase activity."J. Biol. Chem. 278:15905-15910(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation."Cell Cycle 5:71-77(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage."Mol. Cell 22:383-394(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
  15. "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."Nat. Cell Biol. 8:1277-1283(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation."Am. J. Hum. Genet. 80:561-566(2007) [PubMed] [Europe PMC] [Abstract]
  17. "The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A."Cancer Res. 68:5014-5022(2008) [PubMed] [Europe PMC] [Abstract]
  18. "mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase."Cell Cycle 7:373-381(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression."J. Biol. Chem. 284:33320-33332(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  23. "A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome."Clin. Genet. 77:141-144(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  27. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the winged helix-turn-helix motif of human cul-4b."Submitted (APR-2007) to the PDB data bank
  30. "The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation."Cell 147:1024-1039(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Crystal structure of the N-terminal domain of human Cul4B at 2.57 A resolution."Submitted (OCT-2011) to the PDB data bank
  32. "Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor." Am. J. Hum. Genet. 80:345-352(2007) [PubMed] [Europe PMC] [Abstract]
  33. "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation." Nat. Genet. 41:535-543(2009) [PubMed] [Europe PMC] [Abstract]