Calcitonin Receptor Like Protein (CALCRL)

protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.The mRNA species produced encode polyproteins cleaved by posttranslational events to yield either calcitonin (CT), the major gene product in the thyroid, or a predicted 37-amino acid amidated peptide, the calcitonin gene-related peptide (CGRP, or CGRP1). A second gene encoding a similar peptide (CGRP2, or CALCB) has been identified in man as well as in the rat. Receptors for CGRP have been located in the central nervous system by receptor-binding studies and visualized by optoradiography.