Docking protein 2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.The DOK2 cDNA clone encodes a 412-amino acid protein with a molecular mass of 53 to 56 kD. The DOK2 protein has a potential pleckstrin homology (PH) domain at the N terminus, 13 potential tyrosine phosphorylation sites, 6 PXXP motifs, and 2 YXXPXD motifs (predicted Ras-GAP SH2 domain binding sites). It shares 34.8% overall amino acid identity with another tyrosine-phosphorylated protein, p62dok (DOK1), which also contains a predicted PH domain at its N terminus.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Docking Protein 2 (DOK2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Docking Protein 2 (DOK2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Docking Protein 2 (DOK2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Docking Protein 2 (DOK2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Docking Protein 2 (DOK2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Docking Protein 2 (DOK2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Docking Protein 2 (DOK2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Docking Protein 2 (DOK2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Docking Protein 2 (DOK2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Docking Protein 2 (DOK2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Docking Protein 2 (DOK2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Docking Protein 2 (DOK2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Docking Protein 2 (DOK2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Docking Protein 2 (DOK2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Docking Protein 2 (DOK2) | ELISA Kit Customized Service Offer |
- "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins."J. Biol. Chem. 273:4827-4830(1998) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Solution structure of the PH and IRS domains of human docking protein 2, isoform A."Submitted (OCT-2006) to the PDB data bank