Docking Protein 2 (DOK2)

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P56DOK; p56dok-2; Downstream of tyrosine kinase 2

Docking Protein 2 (DOK2)
Docking protein 2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.The DOK2 cDNA clone encodes a 412-amino acid protein with a molecular mass of 53 to 56 kD. The DOK2 protein has a potential pleckstrin homology (PH) domain at the N terminus, 13 potential tyrosine phosphorylation sites, 6 PXXP motifs, and 2 YXXPXD motifs (predicted Ras-GAP SH2 domain binding sites). It shares 34.8% overall amino acid identity with another tyrosine-phosphorylated protein, p62dok (DOK1), which also contains a predicted PH domain at its N terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Docking Protein 2 (DOK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Docking Protein 2 (DOK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Docking Protein 2 (DOK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Docking Protein 2 (DOK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Docking Protein 2 (DOK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Docking Protein 2 (DOK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Docking Protein 2 (DOK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Docking Protein 2 (DOK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Docking Protein 2 (DOK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Docking Protein 2 (DOK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Docking Protein 2 (DOK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Docking Protein 2 (DOK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Docking Protein 2 (DOK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Docking Protein 2 (DOK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Docking Protein 2 (DOK2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins."J. Biol. Chem. 273:4827-4830(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure of the PH and IRS domains of human docking protein 2, isoform A."Submitted (OCT-2006) to the PDB data bank