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Signal Recognition Particle Receptor (SRPR)

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DP; SRP-alpha; Sralpha; Docking Protein; Signal recognition particle receptor subunit alpha

Signal Recognition Particle Receptor (SRPR)
CCC F378
HGNC 11307
MGI 1914648
PubMed 16675701
RGD 1311504
UniProt P08240
Wiki SRPR
The signal recognition particle receptor, also termed 'docking protein,' is an integral membrane protein of the endoplasmic reticulum (ER). Interaction of the SRPR with the signal recognition particle (SRP) on the arrested ribosome is essential for the protein targeting process in the ER membrane. SRP recognizes the signal sequences of nascent secretory proteins and arrests the elongation of the polypeptide chain, thus preventing completion of the presecretory protein. SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts the SRPR, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to dock with the ribosome, leading to insertion of the signal peptide into the translocation channel.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF378Hu01 Recombinant Signal Recognition Particle Receptor (SRPR) Positive Control; Immunogen; SDS-PAGE; WB.
RPF378Hu02 Recombinant Signal Recognition Particle Receptor (SRPR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle Receptor (SRPR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle Receptor (SRPR) Polyclonal Antibody Customized Service Offer
Assay Kits SEF378Hu ELISA Kit for Signal Recognition Particle Receptor (SRPR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle Receptor (SRPR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle Receptor (SRPR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle Receptor (SRPR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle Receptor (SRPR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle Receptor (SRPR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle Receptor (SRPR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle Receptor (SRPR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle Receptor (SRPR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle Receptor (SRPR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle Receptor (SRPR) ELISA Kit Customized Service Offer
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  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains."J. Biol. Chem. 281:8898-8906(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Signal recognition particle receptor exposes the ribosomal translocon binding site."Science 312:745-747(2006) [PubMed] [Europe PMC] [Abstract]