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Signal Recognition Particle 54kDa (SRP54)

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Signal Recognition Particle 54kDa (SRP54)
CCC F381
HGNC 11301
MGI 3714359
PubMed 18953414
RGD 621390
UniProt P61011
The signal recognition particle (SRP) is a ribonucleoprotein complex that mediates the targeting of proteins to the endoplasmic reticulum (ER). The complex consists of a 7S (or 7SL) RNA and 6 different proteins, SRP9 , SRP14, SRP19, SRP54, SRP68, and SRP72. SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts the signal recognition particle receptor, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to dock with the ribosome, leading to insertion of the signal peptide into the translocation channel.SRP54 binds to SRP RNA via the M-domain, but only in the presence of RNA-bound SRP19, and that it associates with the signal peptide of nascent polypeptide chains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle 54kDa (SRP54) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle 54kDa (SRP54) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle 54kDa (SRP54) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle 54kDa (SRP54) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle 54kDa (SRP54) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle 54kDa (SRP54) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle 54kDa (SRP54) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle 54kDa (SRP54) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle 54kDa (SRP54) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle 54kDa (SRP54) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle 54kDa (SRP54) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle 54kDa (SRP54) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle 54kDa (SRP54) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle 54kDa (SRP54) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle 54kDa (SRP54) ELISA Kit Customized Service Offer
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  2. "Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites."Gene 207:197-207(1998) [PubMed] [Europe PMC] [Abstract]
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  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding."J. Mol. Biol. 292:697-705(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Induced structural changes of 7SL RNA during the assembly of human signal recognition particle."Nat. Struct. Biol. 9:740-744(2002) [PubMed] [Europe PMC] [Abstract]