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Signal Recognition Particle 14kDa (SRP14)

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ALURBP; Homologous Alu RNA-Binding Protein; 18 kDa Alu RNA-binding protein

Signal Recognition Particle 14kDa (SRP14)
CCC F383
HGNC 11299
MGI 107169
PubMed 8923743
RGD 1308506
UniProt P37108
The signal recognition particle (SRP) is a ribonucleoprotein complex that mediates the targeting of proteins to the endoplasmic reticulum (ER). The proteins are bound to the 7S RNA as monomers (SRP19 and SRP54) or heterodimers (SRP9/SRP14 and SRP68/SRP72). SRP9 and SRP14 constitute the Alu domain of 7S, whereas the other 4 proteins belong to the S domain. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein.
The predicted amino acid sequence was found to be approximately 90% similar to the mouse homolog. The human sequence is longer at the C terminus and the predicted protein is 18 kD rather than 14 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle 14kDa (SRP14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle 14kDa (SRP14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle 14kDa (SRP14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle 14kDa (SRP14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle 14kDa (SRP14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle 14kDa (SRP14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle 14kDa (SRP14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle 14kDa (SRP14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle 14kDa (SRP14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle 14kDa (SRP14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Recognition Particle 14kDa (SRP14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Recognition Particle 14kDa (SRP14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Recognition Particle 14kDa (SRP14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Recognition Particle 14kDa (SRP14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Recognition Particle 14kDa (SRP14) ELISA Kit Customized Service Offer
  1. "The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs."Mol. Biol. Cell 6:471-484(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA."Mol. Cell. Biol. 14:3949-3959(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (FEB-2008) to UniProtKB
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Structure and assembly of the Alu domain of the mammalian signal recognition particle."Nature 408:167-173(2000) [PubMed] [Europe PMC] [Abstract]