Endoplasmic Reticulum Protein 27 (ERP27)

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PDIA8; C12orf46; Protein Disulfide Isomerase Family A,Member 8

Endoplasmic Reticulum Protein 27 (ERP27)
ERP27 is a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins.The deduced 273-amino acid protein has an N-terminal signal sequence, an N-glycosylation site, and a putative ER retention signal, but it lacks the CxxC thioredoxin superfamily active site. ERP27 has a 2-domain structure homologous to the noncatalytic b and b-prime domains of PDI. It shares 65.5% amino acid identity with its mouse ortholog. Serial analysis of gene expression (SAGE) showed highest ERP27 expression in pancreas, with lower levels in spleen, lung, kidney, thymus, and bone marrow. Immunofluorescence studies in COS-7 cells localized ERP27 to the ER. Peptide binding assays and NMR spectroscopy revealed changes in ERp27 conformation upon substrate binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF403Hu01 Recombinant Endoplasmic Reticulum Protein 27 (ERP27) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Protein 27 (ERP27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Protein 27 (ERP27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Protein 27 (ERP27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Protein 27 (ERP27) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF403Mu01 Recombinant Endoplasmic Reticulum Protein 27 (ERP27) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Protein 27 (ERP27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Protein 27 (ERP27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Protein 27 (ERP27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Protein 27 (ERP27) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF403Ra01 Recombinant Endoplasmic Reticulum Protein 27 (ERP27) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Protein 27 (ERP27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Protein 27 (ERP27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Protein 27 (ERP27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Protein 27 (ERP27) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57."J. Biol. Chem. 281:33727-33738(2006) [PubMed] [Europe PMC] [Abstract]