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Stearoyl Coenzyme A Desaturase (SCD)

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FADS5; SCDOS; Fatty Acid desaturase 5; Delta-9-Desaturase; Stearoyl-CoA Desaturase Opposite Strand

Stearoyl Coenzyme A Desaturase (SCD)
CCC F419
HGNC 10571
MGI 98240
PubMed 18460915
RGD 621177
UniProt O00767
Wiki SCD
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF419Hu01 Recombinant Stearoyl Coenzyme A Desaturase (SCD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF419Hu01 Polyclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) WB; IHC; ICC; IP.
MAF419Hu21 Monoclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) WB; IHC; ICC; IP.
Assay Kits SEF419Hu ELISA Kit for Stearoyl Coenzyme A Desaturase (SCD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF419Mu01 Recombinant Stearoyl Coenzyme A Desaturase (SCD) Positive Control; Immunogen; SDS-PAGE; WB.
RPF419Mu02 Recombinant Stearoyl Coenzyme A Desaturase (SCD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF419Mu01 Polyclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) WB; IHC; ICC; IP.
PAF419Mu02 Polyclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) WB; IHC; ICC; IP.
Assay Kits SEF419Mu ELISA Kit for Stearoyl Coenzyme A Desaturase (SCD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF419Ra01 Recombinant Stearoyl Coenzyme A Desaturase (SCD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF419Ra21 Monoclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) WB; IHC; ICC; IP.
PAF419Ra01 Polyclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) WB; IHC; ICC; IP.
Assay Kits SEF419Ra ELISA Kit for Stearoyl Coenzyme A Desaturase (SCD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF419Fi01 Recombinant Stearoyl Coenzyme A Desaturase (SCD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stearoyl Coenzyme A Desaturase (SCD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stearoyl Coenzyme A Desaturase (SCD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stearoyl Coenzyme A Desaturase (SCD) ELISA Kit Customized Service Offer
  1. "Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites."Biochem. J. 340:255-264(1999) [PubMed] [Europe PMC] [Abstract]
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  6. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues."Int. J. Cancer 57:348-352(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]