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F-Box Protein 5 (FBXO5)

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EMI1; FBX5; Fbxo31; Early mitotic inhibitor 1

F-Box Protein 5 (FBXO5)
CCC F425
HGNC 13584
MGI 1914391
PubMed 15577895
RGD 1309405
UniProt Q9UKT4
Wiki FBXO5
F-box only protein 5 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 5 (FBXO5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 5 (FBXO5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 5 (FBXO5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 5 (FBXO5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 5 (FBXO5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 5 (FBXO5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 5 (FBXO5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 5 (FBXO5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 5 (FBXO5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 5 (FBXO5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 5 (FBXO5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 5 (FBXO5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 5 (FBXO5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 5 (FBXO5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 5 (FBXO5) ELISA Kit Customized Service Offer
  1. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  2. "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)."Nat. Cell Biol. 4:358-366(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase."Dev. Cell 4:813-826(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1."Mol. Biol. Cell 15:5623-5634(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome."Proc. Natl. Acad. Sci. U.S.A. 101:7937-7942(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1."Cell 124:367-380(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor."Genes Dev. 20:2410-2420(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]