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F-Box Protein 11 (FBXO11)

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FBX11; PRMT9; VIT1; UBR6; Ubiquitin Protein Ligase E3 Component N-Recognin 6; Protein arginine N-methyltransferase 9; Vitiligo-associated protein 1

F-Box Protein 11 (FBXO11)
CCC F431
HGNC 13590
MGI 2147134
PubMed 22113614
RGD 727935
UniProt Q86XK2
Wiki FBXO11
F-box only protein 11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 11 (FBXO11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 11 (FBXO11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 11 (FBXO11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 11 (FBXO11) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 11 (FBXO11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 11 (FBXO11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 11 (FBXO11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 11 (FBXO11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 11 (FBXO11) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 11 (FBXO11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 11 (FBXO11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 11 (FBXO11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 11 (FBXO11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 11 (FBXO11) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 11 (FBXO11) ELISA Kit Customized Service Offer
  1. "FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity."J. Biol. Chem. 282:1797-1804(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A family of mammalian F-box proteins."Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "'VIT1', a novel gene associated with vitiligo."Pigment Cell Res. 14:475-484(2001) [PubMed] [Europe PMC] [Abstract]
  9. "FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues."Biochem. Biophys. Res. Commun. 342:472-481(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of TGF-beta signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2."Cell Cycle 12:2175-2182(2013) [PubMed] [Europe PMC] [Abstract]
  11. "CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration."Mol. Cell 49:1147-1158(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase."Mol. Cell 49:1159-1166(2013) [PubMed] [Europe PMC] [Abstract]
  13. "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation."Dev. Cell 28:697-710(2014) [PubMed] [Europe PMC] [Abstract]
  14. "BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans."PLoS Genet. 10:E1004428-E1004428(2014) [PubMed] [Europe PMC] [Abstract]
  15. "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas."Nature 481:90-93(2012) [PubMed] [Europe PMC] [Abstract]