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Tetraspanin 12 (TSPAN12)

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NET-2; TM4SF12; Transmembrane 4 Superfamily Member 12

Tetraspanin 12 (TSPAN12)
CCC F447
HGNC 21641
MGI 1889818
PubMed 22427576
RGD 1311102
UniProt O95859
Wiki TSPAN12
TSPAN12is a tetraspanin protein that is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.Its main binding partner is the ADAM10 protein, a sheddase that interacts with a variety of adhesion molecules that are found on the cell membrane including L1-CAM, E-Cadherin, N-Cadherin and CD44. It also binds to the MT1-MMP metalloprotease protein that is closely related to ADAM10 but has a minimal effect on promotion of expression and function. TSPAN12 also seems to regulate vascular development, as shown by a study involving TSPAN12 knockout mice.The deduced 305-amino acid protein contains 4 transmembrane segments, 4 cysteines in the second extracellular region, including the conserved CCG sequence, and a weakly conserved PxSC motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tetraspanin 12 (TSPAN12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tetraspanin 12 (TSPAN12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tetraspanin 12 (TSPAN12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tetraspanin 12 (TSPAN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tetraspanin 12 (TSPAN12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tetraspanin 12 (TSPAN12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tetraspanin 12 (TSPAN12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tetraspanin 12 (TSPAN12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tetraspanin 12 (TSPAN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tetraspanin 12 (TSPAN12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tetraspanin 12 (TSPAN12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tetraspanin 12 (TSPAN12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tetraspanin 12 (TSPAN12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tetraspanin 12 (TSPAN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tetraspanin 12 (TSPAN12) ELISA Kit Customized Service Offer
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  7. "Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein."FASEB J. 23:3674-3681(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis."Mol. Biol. Cell 20:2030-2040(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Next-generation sequencing of a 40 Mb linkage interval reveals TSPAN12 mutations in patients with familial exudative vitreoretinopathy."Am. J. Hum. Genet. 86:240-247(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in TSPAN12 cause autosomal-dominant familial exudative vitreoretinopathy."Am. J. Hum. Genet. 86:248-253(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Recessive mutations in TSPAN12 cause retinal dysplasia and severe familial exudative vitreoretinopathy (FEVR)."Invest. Ophthalmol. Vis. Sci. 53:2873-2879(2012) [PubMed] [Europe PMC] [Abstract]